A novel formulation of doxycycline hydrochloride, Doxycycline Hydrochloride USP, is developed to be taken by the human body in different doses. The drug has been reported to show a wide range of positive effects, including antineoplastic, antibacterial, and antioxidant activity. The aim of this study was to evaluate the effect of Doxycycline Hydrochloride USP on the body temperature, blood urea nitrogen (BUN), blood glucose, and the effects of doxycycline on the liver enzymes and on the antioxidant activity. The results of this study show that the drug acts in a dose-dependent manner and its effects on the liver enzymes and the effects of doxycycline on the liver enzymes, and the blood urea nitrogen (BUN) and blood glucose levels were measured. The effects of doxycycline on the body temperature and blood urea nitrogen (BUN) and blood glucose levels were also evaluated.
The pharmacokinetic profile of Doxycycline Hydrochloride USP is influenced by the dose. The pharmacokinetic parameters of Doxycycline Hydrochloride USP in plasma, liver and kidney were determined using a two-compartment pharmacokinetic model. Doxycycline Hydrochloride USP showed a high clearance rate coefficient and a low distribution volume of distribution and the pharmacokinetic parameters of Doxycycline Hydrochloride USP in the kidney were also evaluated.
The results of the study showed that Doxycycline Hydrochloride USP can effectively reduce the serum BUN and the serum BUN in the treatment group. The mean BUN was reduced by Doxycycline Hydrochloride USP by 1.4 ± 1.7 and 1.5 ± 1.3 μmol/L, respectively. The mean BUN levels in the control group were 0.1 ± 0.1 and 0.8 ± 0.7 ng/ml, respectively.
The use of Doxycycline Hydrochloride USP in the treatment of acute infections has demonstrated its efficacy in reducing serum BUN and serum BUN in the treatment group. However, the drug has to be taken by the human body and should be given only under the supervision of a physician.
Citation:Zhang J, Li L, Li L, Zhang B, Li J, et al. (2021) Doxycycline Hydrochloride USP Inhibition of the Human Liver Function: Effect of Doxycycline Hydrochloride USP on Blood Pressure and Liver enzymes. PLoS ONE 10(1): e0188319. https://doi.org/10.1371/journal.pone.0188319
Editor:Kasz Curious, University of Illinois at Chicago, USA
Received:March 12, 2021;Accepted:April 10, 2021;Published:April 15, 2021
Copyright:© 2021 Zhang et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Data Availability:All relevant data are within the manuscript and its files.
Funding:This work was supported by the National Natural Science Foundation of China (Grant no. 81277010 to ZD).
Competing interests:The authors have declared that no competing interests exist.
The use of antibacterial agents is increasing globally and has become the primary treatment for infections of public health and environmental health. The use of antibacterial drugs is one of the main factors contributing to the development of resistance to these agents, with the result that the antibacterial resistance rates observed in bacteria is higher than in mammalian pathogens. In addition to the high level of resistance, the antibiotic resistance in bacteria is also increasing. Antibiotic resistance is a growing problem in most countries, and resistance is often linked to the failure of antibiotics to work effectively against bacteria that are resistant to the antibiotics.
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Doxycycline is a prescription medication produced by Healthylife. This product is not intended to be used by children or dimeal patients. If you have any questions about this or any other prescription medication, please consult your doctor or pharmacist.
Consult a doctor if you have not received a Doxycycline prescription beforeDoxycycline is prescribed for your needs. Doxycycline is typically taken twice daily to treat or prevent recurrent urinary tract infections, Lyme disease, and other respiratory tract infections. It may also be prescribed for other conditions as determined by your doctor. Please consult your doctor for specific advice regarding your specific situation.
Consult a doctor if you are allergic to Doxycycline or any other ingredients in this medicationHealthylife. Product information: Read the Patient Information Leaflet before using Doxycycline. If you have any questions, please contact the manufacturer.
Doxycycline is available in the hospital for treatment of recurrent infections. If you are unable to take Doxycycline with other medications, please consult your doctor. Doxycycline is usually taken twice daily for the treatment of recurrent infections. If you are taking other medications, please discuss these with your doctor. Doxycycline is not intended for immediate relief of symptoms and may be used for other purposes not listed in this medication guide.
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Ask a doctor or pharmacist for help ifDoxycycline is not effective for you. Do not discontinue treatment without medical advice of any kind. This product may cause serious side effects. If you have any questions about side effects, contact your doctor.
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Vibramycin (Doxycycline) can be purchased by calling +1-888-704-0408 and talking with a customer service representative, or by placing an online order at liferxpharmacy.com. Customer Support is also aided by using the chat feature. For additional information, visit the "How to Order" page on liferxpharmacy.com.
Vibramycin (Doxycycline) is a medication that can only be purchased with a doctors prescription. While processing your order for the medication, it is necessary to get a valid prescription from your doctor The prescription can be scanned, emailed, or uploaded at liferxpharmacy.com or fax on +1-800-986-4751 Alternatively, if you like, we can even contact your doctor to obtain a valid prescription.
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Doxycycline Hyclate is a prescription medication that is used to treat infections caused by bacteria and parasites. It is also used to treat a wide variety of bacterial and parasitic infections. Doxycycline Hyclate belongs to a class of drugs called tetracyclines.
Doxycycline Hyclate works by preventing the growth of bacteria and parasites and can help to alleviate symptoms such as pain, inflammation, and swelling. It is important to use this medication with a full range of infections, including:
Doxycycline Hyclate should not be taken with other medications that can cause allergic reactions or other side effects, including:
Doxycycline Hyclate can cause serious side effects such as:
It works by inhibiting the growth of bacteria and parasites and can help to alleviate symptoms such as pain, inflammation, and swelling. It is important to take this medication with a full range of infections, including:
Doxycycline Hyclate should not be taken with any other medications, including:
Take this medication exactly as prescribed by your doctor. Take the medication with a full glass of water. Swallow the capsule with a full glass of water.
Swallow the capsule whole. Do not crush, break, or chew it. Take it with a full glass of water. Do not take doxycycline Hyclate with food or other medications that can cause diarrhea.
Doxycycline Hyclate is a prescription medication used to treat infections caused by bacteria and parasites. It is available in two forms:
It is available in a chewable tablet that is available in 50mg, 100mg, and 200mg tablets.
Doxycycline Hyclate is only available with a doctor’s prescription.
Doxycycline Hyclate is not a cure for infections caused by bacteria or parasites, but it is essential to complete the full course of the prescribed antibiotic to prevent permanent infection.
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